Thermo Fisher Scientific Unveils Krios 5 Cryo-TEM for Enhanced Molecular Imaging

The system incorporates AI-powered automation and enhanced optics, aiming to refine single particle analysis (SPA) and cryo-electron tomography (cryo-ET)—two key techniques in structural biology.

Thermo Fisher Scientific has launched the Krios 5 Cryo-Transmission Electron Microscope (Cryo-TEM), an advanced atomic-resolution platform designed to improve productivity and performance in molecular imaging.

The system incorporates AI-powered automation and enhanced optics, aiming to refine single particle analysis (SPA) and cryo-electron tomography (cryo-ET)—two key techniques in structural biology.

With an up to 25% increase in throughput compared to earlier models, the Krios 5 enables high-fidelity 3D visualization of proteins and their interactions within cells. The platform is expected to aid researchers in studying viruses, proteins, and cellular structures at an atomic level, offering deeper insights into biological mechanisms.

Key Enhancements in Cryo-TEM Technology

The Krios 5 Cryo-TEM introduces several technological upgrades to support research in molecular and structural biology:

• AI-powered experimental setup to streamline workflows and improve imaging precision.

• Enhanced data acquisition capabilities for improved sample analysis.

• Vacuum capsule transfer system, designed to reduce contamination during cryo-ET workflows.

These improvements are aimed at facilitating drug discovery and biomedical research, allowing scientists to analyze molecular structures with greater accuracy and efficiency.

Impact on Drug Discovery and Biomedical Research

By refining cryo-EM technology, Thermo Fisher's latest innovation is positioned to play a crucial role in the development of new treatments.

The enhanced imaging capabilities will enable researchers to examine protein structures in greater detail, supporting advancements in disease modeling and therapeutic design.

The Krios 5 builds upon Thermo Fisher’s established legacy in cryo-electron microscopy, offering researchers a more efficient platform for studying biological mechanisms at the molecular level.