Mount Sinai Opens New AI Research Center in Manhattan

The project builds on Mount Sinai's three-year development of the Windreich Department of AI and Human Health, which seeks to integrate AI across clinical and operational processes.

The Mount Sinai Health System has inaugurated its new research facility, the Hamilton and Amabel James Center for AI and Human Health, in Manhattan.

The 12-floor center aims to revolutionize healthcare delivery through artificial intelligence, supporting the system’s eight hospitals and 400 ambulatory clinics.

The project builds on Mount Sinai's three-year development of the Windreich Department of AI and Human Health, which seeks to integrate AI across clinical and operational processes.

Central to its mission is creating an “intelligent fabric” to enhance healthcare system efficiency and improve patient care.

The center will house eight AI-focused departments from the Icahn School of Medicine at Mount Sinai, including the Hasso Plattner Institute of Digital Health, the Institute for Genomic Health, the Division of Medical Genetics and Genomics, the BioMedical Engineering and Imaging Institute, and the Institute for Personalized Medicine.

Backed by a $100 million donation from Hamilton Evans "Tony" James, executive vice chairman of Blackstone, and his wife, Amabel, the facility is designed to accommodate 40 principal investigators and 250 graduate students, postdoctoral fellows, computer scientists, and staff.

Proprietary AI Innovations

Mount Sinai has developed proprietary AI systems to enhance clinical operations, including NutriScan AI, a tool to identify patients with malnutrition that earned a Hearst Health Award in 2024.

These homegrown AI tools, which are not regulated federally, reflect the system’s focus on internal innovation over external partnerships.

Mount Sinai is also a founding partner of the Coalition for Health AI, a collaborative effort to establish standards and validate AI tools in healthcare.

With this new facility, Mount Sinai is positioning itself as a leader in AI-driven healthcare innovation, competing with major tech companies by leveraging its extensive medical data and internal expertise.

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