IISER Bhopal Develops Clear, Safe, Biomedical Adhesive for Tissue Repair

These biodegradable and biocompatible adhesives hold immense potential in several fields, including medicine, dentistry, drug delivery, and tissue engineering.

A team of researchers at the Indian Institute of Science Education and Research (IISER) Bhopal has created a clear, biodegradable, biocompatible biomedical adhesive.

This adhesive can effectively seal and repair injured tissues, offering a promising application solution.

The adhesive can securely bind different surfaces, including tissues, bones, eggshells, and wood, both in the air and underwater. Notably, it achieves this without the need for additional crosslinking agents or metal ions.

These biodegradable and biocompatible adhesives hold immense potential in several fields, including medicine, dentistry, drug delivery, and tissue engineering.

In the field of orthopaedics, these biomedical adhesives can enhance bone repair and serve as an alternative to traditional methods such as sutures, staples, and wires for wound closures. Furthermore, their eco-friendly nature makes them suitable for packaging applications, promoting sustainability across various industries.

The researchers achieved this breakthrough using a mixture of oppositely charged water-soluble polyelectrolytes known for their biodegradability and biocompatibility.

These polymers contain multiple amide groups and thiol residues, which create strong adhesion by forming hydrogen and disulfide bonds. The resulting adhesive layer remains clear and transparent.

The adhesive formulations developed by the IISER team also hold promise for cosmetic and biological applications.

In another significant development, scientists from IISER Bhopal made important advances in understanding circular RNA's role in viral infections, particularly HIV-1. This circRNA plays a pivotal role in replicating the HIV-1 virus within the human body, aiding its multiplication.

The study aimed to shed light on the mysteries surrounding circRNA, a less abundant and more challenging-to-detect molecule, especially during viral infections such as HIV-1.